LMO4

Protein-coding gene in the species Homo sapiens
LMO4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2L4Z

Identifiers
AliasesLMO4, LIM domain only 4
External IDsOMIM: 603129; MGI: 109360; HomoloGene: 4927; GeneCards: LMO4; OMA:LMO4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for LMO4
Genomic location for LMO4
Band1p22.3Start87,328,880 bp[1]
End87,348,923 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for LMO4
Genomic location for LMO4
Band3 H2|3 68.61 cMStart143,894,291 bp[2]
End143,910,981 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • dorsolateral prefrontal cortex

  • prefrontal cortex

  • Brodmann area 46

  • superior frontal gyrus

  • parietal lobe

  • postcentral gyrus

  • Brodmann area 9

  • frontal pole

  • cingulate gyrus

  • anterior cingulate cortex
Top expressed in
  • granulocyte

  • genital tubercle

  • cingulate gyrus

  • superior frontal gyrus

  • visual cortex

  • primary motor cortex

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • CA3 field

  • corneal stroma
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • metal ion binding
  • protein binding
  • cis-regulatory region sequence-specific DNA binding
  • transcription factor binding
Cellular component
  • transcription regulator complex
  • cell leading edge
Biological process
  • regulation of transcription, DNA-templated
  • ventricular septum development
  • spinal cord association neuron differentiation
  • thymus development
  • negative regulation of protein-containing complex assembly
  • transcription, DNA-templated
  • ventral spinal cord interneuron differentiation
  • regulation of cell activation
  • spinal cord motor neuron differentiation
  • regulation of cell fate specification
  • positive regulation of transcription by RNA polymerase II
  • neural tube closure
  • transcription by RNA polymerase II
  • positive regulation of kinase activity
  • regulation of cell migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8543

16911

Ensembl

ENSG00000143013

ENSMUSG00000028266

UniProt

P61968

P61969

RefSeq (mRNA)

NM_006769
NM_001369491

NM_001161769
NM_001161770
NM_010723

RefSeq (protein)

NP_006760
NP_001356420

NP_001155241
NP_001155242
NP_034853

Location (UCSC)Chr 1: 87.33 – 87.35 MbChr 3: 143.89 – 143.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.[5]

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.[5]

Interactions

LMO4 has been shown to interact with LDB1,[6][7] RBBP8[6][8] and BRCA1.[6][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143013 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028266 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LMO4 LIM domain only 4".
  6. ^ a b c Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972.
  7. ^ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888.
  8. ^ a b Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867.

Further reading

  • Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. Bibcode:1998PNAS...9511257K. doi:10.1073/pnas.95.19.11257. PMC 21629. PMID 9736723.
  • Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene". Biochim. Biophys. Acta. 1445 (1): 148–53. doi:10.1016/s0167-4781(99)00037-8. PMID 10209267.
  • Tse E, Grutz G, Garner AA, et al. (2000). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping". Mamm. Genome. 10 (11): 1089–94. doi:10.1007/s003359901167. PMID 10556429. S2CID 19479121.
  • Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
  • Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR. 23 (2): 165–6. doi:10.1023/A:1016363414644. PMID 12153047. S2CID 30891765.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vu D, Marin P, Walzer C, et al. (2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells". Brain Res. Mol. Brain Res. 115 (2): 93–103. doi:10.1016/S0169-328X(03)00119-0. PMID 12877980.
  • Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
  • Sutherland KD, Visvader JE, Choong DY, et al. (2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8. doi:10.1002/ijc.11343. PMID 12925972.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction". J. Biol. Chem. 280 (13): 12747–57. doi:10.1074/jbc.M500175200. PMID 15677447.
  • Sun T, Patoine C, Abu-Khalil A, et al. (2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex". Science. 308 (5729): 1794–8. Bibcode:2005Sci...308.1794S. doi:10.1126/science.1110324. PMC 2756725. PMID 15894532.
  • Sum EY, Segara D, Duscio B, et al. (2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7659–64. Bibcode:2005PNAS..102.7659S. doi:10.1073/pnas.0502990102. PMC 1140463. PMID 15897450.
  • Jeffries CM, Graham SC, Stokes PH, et al. (2007). "Stabilization of a binary protein complex by intein-mediated cyclization". Protein Sci. 15 (11): 2612–8. doi:10.1110/ps.062377006. PMC 2242402. PMID 17001033.
  • v
  • t
  • e
  • 1rut: Complex of LMO4 LIM domains 1 and 2 with the ldb1 LID domain
    1rut: Complex of LMO4 LIM domains 1 and 2 with the ldb1 LID domain
  • 2dfy: Crystal structure of a cyclized protein fusion of LMO4 LIM domains 1 and 2 with the LIM interacting domain of LDB1
    2dfy: Crystal structure of a cyclized protein fusion of LMO4 LIM domains 1 and 2 with the LIM interacting domain of LDB1


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