GPX8

Protein-coding gene in the species Homo sapiens
GPX8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3CYN, 3KIJ

Identifiers
AliasesGPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)
External IDsOMIM: 617172; MGI: 1916840; HomoloGene: 88454; GeneCards: GPX8; OMA:GPX8 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GPX8
Genomic location for GPX8
Band5q11.2Start55,160,167 bp[1]
End55,167,297 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for GPX8
Genomic location for GPX8
Band13|13 D2.2Start113,179,287 bp[2]
End113,182,944 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • tibia

  • germinal epithelium

  • placenta

  • smooth muscle tissue

  • Achilles tendon

  • parietal pleura

  • gonad

  • synovial membrane

  • corpus epididymis
Top expressed in
  • calvaria

  • belly cord

  • efferent ductule

  • Epithelium of choroid plexus

  • vestibular sensory epithelium

  • decidua

  • interventricular septum

  • uterus

  • intercostal muscle

  • cervix
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity
  • glutathione peroxidase activity
  • peroxidase activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum lumen
  • membrane
Biological process
  • response to oxidative stress
  • cellular oxidant detoxification
  • cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

493869

69590

Ensembl

ENSG00000164294

ENSMUSG00000021760

UniProt

Q8TED1

Q9D7B7

RefSeq (mRNA)

NM_001008397
NM_001306197
NM_001306198
NM_001306201

NM_027127

RefSeq (protein)

NP_001008398
NP_001293126
NP_001293127
NP_001293130

NP_081403

Location (UCSC)Chr 5: 55.16 – 55.17 MbChr 13: 113.18 – 113.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.[5][6] GPx-8 is a member of the glutathione peroxidase family.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164294 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021760 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: glutathione peroxidase 8 (putative)".
  6. ^ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Glutathione Peroxidase 8 (GPX8)
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