GMPPB

GMPPB
Identifiers
AliasesGMPPB, MDDGA14, MDDGB14, MDDGC14, GDP-mannose pyrophosphorylase B, LGMDR19
External IDsOMIM: 615320; MGI: 2660880; HomoloGene: 5578; GeneCards: GMPPB; OMA:GMPPB - orthologs
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[1]
Chromosome 9 (mouse)
Genomic location for GMPPB
Genomic location for GMPPB
Band9|9 F1Start107,926,441 bp[1]
End107,930,000 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • anterior pituitary

  • bone marrow cells

  • right lobe of thyroid gland

  • minor salivary glands

  • right lobe of liver

  • left lobe of thyroid gland

  • right adrenal gland

  • left adrenal gland

  • body of stomach
Top expressed in
  • epithelium of small intestine

  • intestinal villus

  • Ileal epithelium

  • jejunum

  • duodenum

  • islet of Langerhans

  • spermatid

  • proximal tubule

  • placenta

  • colon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • mannose-1-phosphate guanylyltransferase activity
  • nucleotide binding
  • nucleotidyltransferase activity
  • GTP binding
  • protein binding
Cellular component
  • cytoplasm
Biological process
  • biosynthesis
  • GDP-mannose biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29925

331026

Ensembl

n/a

ENSMUSG00000070284

UniProt

Q9Y5P6

Q8BTZ7

RefSeq (mRNA)

NM_021971
NM_013334

NM_177910
NM_001357682

RefSeq (protein)

NP_037466
NP_068806

NP_808578
NP_001344611

Location (UCSC)n/aChr 9: 107.93 – 107.93 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Mannose-1-phosphate guanyltransferase beta is an enzyme that in humans is encoded by the GMPPB gene.[4]

This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. The gene encodes two transcript variants.[4]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070284 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: GMPPB GDP-mannose pyrophosphorylase B".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ono T, Sekino-Suzuki N, Kikkawa Y, et al. (2003). "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons". J. Neurosci. 23 (13): 5887–96. doi:10.1523/JNEUROSCI.23-13-05887.2003. PMC 6741272. PMID 12843293.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Ning B, Elbein AD (2001). "Cloning, expression and characterization of the pig liver GDP-mannose pyrophosphorylase. Evidence that GDP-mannose and GDP-Glc pyrophosphorylases are different proteins". Eur. J. Biochem. 267 (23): 6866–74. doi:10.1046/j.1432-1033.2000.01781.x. PMID 11082198.


  • v
  • t
  • e