Protein-coding gene in the species Homo sapiens
| FZD3 |
|---|
|
| Identifiers |
|---|
| Aliases | FZD3, Fz-3, frizzled class receptor 3 |
|---|
| External IDs | OMIM: 606143; MGI: 108476; HomoloGene: 23004; GeneCards: FZD3; OMA:FZD3 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 8 (human)[1] |
|---|
| | Band | 8p21.1 | Start | 28,494,205 bp[1] |
|---|
| End | 28,574,267 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 14 (mouse)[2] |
|---|
| | Band | 14 D1|14 34.09 cM | Start | 65,429,898 bp[2] |
|---|
| End | 65,499,912 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - Brodmann area 23
- secondary oocyte
- corpus epididymis
- middle temporal gyrus
- endothelial cell
- entorhinal cortex
- parietal lobe
- postcentral gyrus
- cerebellar vermis
- buccal mucosa cell
|
| | Top expressed in | - medial ganglionic eminence
- Rostral migratory stream
- anterior amygdaloid area
- olfactory tubercle
- ventromedial nucleus
- vestibular sensory epithelium
- trigeminal ganglion
- substantia nigra
- lateral septal nucleus
- paraventricular nucleus of hypothalamus
|
| | More reference expression data |
|
|---|
| BioGPS |  | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - PDZ domain binding
- signal transducer activity
- Wnt-protein binding
- protein binding
- transmembrane signaling receptor activity
- G protein-coupled receptor activity
- Wnt-activated receptor activity
| | Cellular component | - cytoplasm
- lateral plasma membrane
- membrane
- plasma membrane
- apical part of cell
- presynaptic active zone
- cell surface
- axon
- filopodium tip
- neuronal cell body
- dendrite
- apical plasma membrane
- integral component of membrane
| | Biological process | - hair follicle development
- dopaminergic neuron axon guidance
- positive regulation of neuroblast proliferation
- sympathetic ganglion development
- G protein-coupled receptor signaling pathway
- negative regulation of execution phase of apoptosis
- negative regulation of mitotic cell cycle, embryonic
- serotonergic neuron axon guidance
- establishment of planar polarity
- cell proliferation in midbrain
- neuron migration
- Wnt signaling pathway
- commissural neuron axon guidance
- nervous system development
- multicellular organism development
- neural tube closure
- cell surface receptor signaling pathway
- inner ear morphogenesis
- neuron differentiation
- post-anal tail morphogenesis
- canonical Wnt signaling pathway
- midbrain morphogenesis
- midbrain development
- signal transduction
- response to electrical stimulus
- Wnt signaling pathway, calcium modulating pathway
- brain development
- planar cell polarity pathway involved in axon guidance
- Wnt signaling pathway, planar cell polarity pathway
- non-canonical Wnt signaling pathway
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | | |
|---|
| RefSeq (protein) | | |
|---|
| Location (UCSC) | Chr 8: 28.49 – 28.57 Mb | Chr 14: 65.43 – 65.5 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Frizzled-3 (Fz-3) is a protein that in humans is encoded by the FZD3 gene.[5][6][7]
Function
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000104290 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007989 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
- ^ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
- ^ a b "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
- ^ Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife. 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
- ^ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A. 111 (29): E3005-14. Bibcode:2014PNAS..111E3005H. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.
Further reading
- Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID 12011974.
- Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID 10491302.
- Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes". J. Invest. Dermatol. 116 (6): 940–6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
- Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia". Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID 14642436. S2CID 109984.
- Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID 15274031. S2CID 33599450.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
- Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders". Journal of Neural Transmission. 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID 15657645. S2CID 22324795.
External links
- "Frizzled Receptors: FZD3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
