FTSJ3

Enzyme
FTSJ3
Identifiers
AliasesFTSJ3, EPCS3, SPB1, FtsJ homolog 3, FtsJ RNA methyltransferase homolog 3, FtsJ RNA 2'-O-methyltransferase 3
External IDsOMIM: 618411; MGI: 1860295; HomoloGene: 5451; GeneCards: FTSJ3; OMA:FTSJ3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for FTSJ3
Genomic location for FTSJ3
Band17q23.3Start63,819,433 bp[1]
End63,830,012 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for FTSJ3
Genomic location for FTSJ3
Band11 E1|11 68.89 cMStart106,139,968 bp[2]
End106,146,905 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • sural nerve

  • tendon of biceps brachii

  • stromal cell of endometrium

  • gastric mucosa

  • right ovary

  • right adrenal gland

  • right lobe of thyroid gland

  • body of uterus

  • canal of the cervix
Top expressed in
  • tail of embryo

  • genital tubercle

  • epiblast

  • ventricular zone

  • yolk sac

  • blastocyst

  • embryo

  • zygote

  • morula

  • morula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • rRNA methyltransferase activity
  • protein binding
  • RNA binding
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
Cellular component
  • nucleus
  • nucleolus
  • preribosome, large subunit precursor
  • preribosome, small subunit precursor
Biological process
  • rRNA processing
  • methylation
  • RNA methylation
  • ribosome biogenesis
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA methylation
  • enzyme-directed rRNA 2'-O-methylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

117246

56095

Ensembl

ENSG00000108592

ENSMUSG00000020706

UniProt

Q8IY81

Q9DBE9

RefSeq (mRNA)

NM_017647

NM_025310

RefSeq (protein)

NP_060117

NP_079586

Location (UCSC)Chr 17: 63.82 – 63.83 MbChr 11: 106.14 – 106.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene.[5]

Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108592 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020706 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: FTSJ3 FtsJ homolog 3 (E. coli)".

Further reading

  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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