Ethacridine lactate
- B05CA08 (WHO) D08AA01 (WHO)
- 7-Ethoxyacridine-3,9-diamine 2-hydroxypropanoic acid
- 1837-57-6 N
- 15789
- 15012 Y
- 7T7T2I9823
- D01248 Y
- ChEMBL582355 Y
- DTXSID10872472
- Interactive image
- O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC
- InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) Y
- Key:IYLLULUTZPKQBW-UHFFFAOYSA-N Y
Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.
Its primary use is as an antiseptic[1] in solutions of 0.1%. It is effective against mostly Gram-positive bacteria, such as Streptococci and Staphylococci, but ineffective against Gram-negative bacteria such as Pseudomonas aeruginosa.[2]
Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.[3] Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.
References
- ^ Merck Index, 11th Ed., 3668
- ^ Adarchenko AA, Krasil'nikov AP, Sobeshchuk OP (1989). "[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa]". Antibiotiki I Khimioterapiia (in Russian). 34 (12): 902–7. PMID 2517004.
- ^ Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and Gynecology. 61 (6): 733–736. PMID 6843933.
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