Ectonucleoside triphosphate diphosphohydrolase 4

Protein-coding gene in the species Homo sapiens
ENTPD4
Identifiers
AliasesENTPD4, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase, ectonucleoside triphosphate diphosphohydrolase 4
External IDsOMIM: 607577; MGI: 5435040; HomoloGene: 68421; GeneCards: ENTPD4; OMA:ENTPD4 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ENTPD4
Genomic location for ENTPD4
Band8p21.3Start23,385,783 bp[1]
End23,457,695 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for ENTPD4
Genomic location for ENTPD4
Band14 D2|14Start69,792,873 bp[2]
End69,822,969 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • middle temporal gyrus

  • tibia

  • endothelial cell

  • lateral nuclear group of thalamus

  • postcentral gyrus

  • Brodmann area 46

  • orbitofrontal cortex

  • tonsil

  • palpebral conjunctiva
Top expressed in
  • proximal tubule

  • quadriceps femoris muscle

  • spermatocyte

  • adrenal gland

  • skeletal muscle tissue

  • human kidney

  • right kidney

  • muscle of thigh

  • urinary bladder

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • hydrolase activity
  • uridine-diphosphatase activity
  • nucleoside-diphosphatase activity
  • nucleoside-triphosphatase activity
Cellular component
  • membrane
  • cytoplasmic vesicle
  • integral component of Golgi membrane
  • Golgi apparatus
  • autophagosome membrane
  • integral component of membrane
  • Golgi membrane
  • integral component of autophagosome membrane
Biological process
  • UDP catabolic process
  • nucleobase-containing small molecule catabolic process
  • metabolism
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9583

100862375

Ensembl

ENSG00000197217

ENSMUSG00000022066

UniProt

Q9Y227
Q8NE73

Q9DBT4

RefSeq (mRNA)

NM_004901
NM_001128930

NM_001359159
NM_001359160

RefSeq (protein)

NP_001122402
NP_004892

NP_080450
NP_001347281

Location (UCSC)Chr 8: 23.39 – 23.46 MbChr 14: 69.79 – 69.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 4 is a protein that in humans is encoded by the ENTPD4 gene. [5]

Function

This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium ion-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197217 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022066 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 4". Retrieved 2018-03-21.

Further reading

  • Biederbick A, Rösser R, Storre J, Elsässer HP (June 2004). "The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70". BMC Biochem. 5: 8. doi:10.1186/1471-2091-5-8. PMC 443525. PMID 15200686.
  • Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL (May 2010). "Human variation in alcohol response is influenced by variation in neuronal signaling genes". Alcohol. Clin. Exp. Res. 34 (5): 800–12. doi:10.1111/j.1530-0277.2010.01152.x. PMID 20201926.
  • Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721. S2CID 23210085.
  • Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K (January 2011). "An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia". Psychiatry Res. 185 (1–2): 9–15. doi:10.1016/j.psychres.2009.09.018. PMID 20537721. S2CID 23210085.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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