E74 like ets transcription factor 3

Protein-coding gene in the species Homo sapiens
ELF3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E8P

Identifiers
AliasesELF3, EPR-1, ERT, ESE-1, ESX, E74 like ETS transcription factor 3
External IDsOMIM: 602191; MGI: 1101781; HomoloGene: 3265; GeneCards: ELF3; OMA:ELF3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ELF3
Genomic location for ELF3
Band1q32.1Start202,007,945 bp[1]
End202,017,183 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ELF3
Genomic location for ELF3
Band1|1 E4Start135,181,313 bp[2]
End135,186,306 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • mucosa of transverse colon

  • rectum

  • pancreatic ductal cell

  • gallbladder

  • body of pancreas

  • minor salivary glands

  • islet of Langerhans

  • right uterine tube

  • palpebral conjunctiva
Top expressed in
  • corneal stroma

  • pyloric antrum

  • epithelium of stomach

  • mucous cell of stomach

  • blastocyst

  • duodenum

  • colon

  • left colon

  • medulla of thymus

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • transcription coactivator activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • cytoplasm
  • nucleus
  • Golgi apparatus
  • cytosol
  • nucleoplasm
Biological process
  • cell differentiation
  • regulation of transcription, DNA-templated
  • epithelial cell differentiation
  • regulation of transcription by RNA polymerase II
  • anatomical structure morphogenesis
  • extracellular matrix organization
  • transcription by RNA polymerase II
  • transcription, DNA-templated
  • multicellular organism development
  • positive regulation of transcription, DNA-templated
  • epidermis development
  • inflammatory response
  • negative regulation of transcription, DNA-templated
  • blastocyst development
  • positive regulation of transcription by RNA polymerase II
  • mammary gland involution
  • positive regulation of Notch signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1999

13710

Ensembl

ENSG00000163435

ENSMUSG00000003051

UniProt

P78545

Q3UPW2

RefSeq (mRNA)

NM_001114309
NM_004433

NM_001163131
NM_007921

RefSeq (protein)

NP_001107781
NP_004424

NP_001156603
NP_031947

Location (UCSC)Chr 1: 202.01 – 202.02 MbChr 1: 135.18 – 135.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E74 like ETS transcription factor 3 is a protein that in humans is encoded by the ELF3 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163435 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003051 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: E74 like ETS transcription factor 3". Retrieved 2018-07-16.

Further reading

  • Neve RM, Ylstra B, Chang CH, Albertson DG, Benz CC (May 2002). "ErbB2 activation of ESX gene expression". Oncogene. 21 (24): 3934–8. doi:10.1038/sj.onc.1205503. PMID 12032832.
  • Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M (October 2002). "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. Bibcode:2002PNAS...9912747A. doi:10.1073/pnas.202162199. PMC 130531. PMID 12242338.
  • Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC (January 2003). "ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells". J. Biol. Chem. 278 (2): 875–84. doi:10.1074/jbc.M208241200. PMID 12414801.
  • Cabral A, Fischer DF, Vermeij WP, Backendorf C (May 2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
  • Lee HJ, Chang JH, Kim YS, Kim SJ, Yang HK (September 2003). "Effect of ets-related transcription factor (ERT) on transforming growth factor (TGF)-beta type II receptor gene expression in human cancer cell lines". J. Exp. Clin. Cancer Res. 22 (3): 477–80. PMID 14582709.
  • Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P (March 2004). "ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation". J. Biol. Chem. 279 (13): 12794–803. doi:10.1074/jbc.M308593200. PMID 14715662.
  • Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A (March 2004). "ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells". Oncogene. 23 (9): 1766–79. doi:10.1038/sj.onc.1207391. PMID 14767472.
  • Wang H, Fang R, Cho JY, Libermann TA, Oettgen P (June 2004). "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86". J. Biol. Chem. 279 (24): 25241–50. doi:10.1074/jbc.M401356200. PMID 15075319.
  • Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A (June 2004). "The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism". Mol. Cell. Biol. 24 (12): 5548–64. doi:10.1128/MCB.24.12.5548-5564.2004. PMC 419891. PMID 15169914.


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