Difluoroacetic acid

Difluoroacetic acid
Names
Preferred IUPAC name
Difluoroacetic acid
Other names
2,2-Difluoroacetic acid
Identifiers
CAS Number
  • 381-73-7 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 10200426
ECHA InfoCard 100.006.218 Edit this at Wikidata
PubChem CID
  • 9788
UNII
  • ZQK1C95K3N checkY
CompTox Dashboard (EPA)
  • DTXSID50896814 DTXSID2059932, DTXSID50896814 Edit this at Wikidata
InChI
  • InChI=1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
    Key: PBWZKZYHONABLN-UHFFFAOYSA-N
  • C(C(=O)O)(F)F
Properties
Chemical formula
 CHF2COOH
Molar mass 96.033 g·mol−1
Density 1.526 g/mL[1]
Melting point −1 °C (30 °F; 272 K)[1]
Boiling point 132–134 °C (270–273 °F; 405–407 K)[1]
Acidity (pKa) 1.33
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Difluoroacetic acid is a chemical compound with formula CHF2COOH. It is a dihalogenocarboxylic acid, specifically a structural analog of acetic acid with two of three hydrogen atoms on the alpha carbon replaced with fluorine atoms. In solution, it dissociates to form difluoroacetate ions. Difluoroacetic acid can also be used as direct C-H difluoromethylating reagent.[2]

See also

References

  1. ^ a b c "Difluoroacetic acid". Sigma-Aldrich.
  2. ^ Tung, Truong Thanh; Christensen, Søren Brøgger; Nielsen, John (2017). "Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds". Chemistry - A European Journal. 23 (72): 18125–18128. doi:10.1002/chem.201704261. PMID 28945302.
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