Deoxyribonuclease ii, lysosomal

Protein-coding gene in the species Homo sapiens
DNASE2
Identifiers
AliasesDNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal, AIPCS
External IDsOMIM: 126350; MGI: 1329019; HomoloGene: 68179; GeneCards: DNASE2; OMA:DNASE2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for DNASE2
Genomic location for DNASE2
Band19p13.13Start12,875,209 bp[1]
End12,881,466 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pancreatic ductal cell

  • stromal cell of endometrium

  • external globus pallidus

  • parotid gland

  • Descending thoracic aorta

  • cardia

  • monocyte

  • vena cava

  • lateral nuclear group of thalamus

  • Pars compacta
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • nuclease activity
  • endonuclease activity
  • endodeoxyribonuclease activity
  • hydrolase activity
  • deoxyribonuclease II activity
Cellular component
  • lysosome
  • extracellular exosome
  • intracellular anatomical structure
Biological process
  • erythrocyte differentiation
  • multicellular organism development
  • DNA metabolic process
  • DNA catabolic process
  • DNA catabolic process, endonucleolytic
  • apoptotic process
  • apoptotic DNA fragmentation
  • regulation of immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1777

13423

Ensembl

ENSG00000105612

ENSMUSG00000003812

UniProt

O00115

P56542

RefSeq (mRNA)

NM_001375

NM_010062
NM_001368295
NM_001368296

RefSeq (protein)

NP_001366
NP_001366.1

NP_034192
NP_001355224
NP_001355225

Location (UCSC)Chr 19: 12.88 – 12.88 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. [4]

Function

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.

Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105612 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.

Further reading

  • Chou SF, Chen HL, Lu SC (2002). "Up-regulation of human deoxyribonuclease II gene expression during myelomonocytic differentiation of HL-60 and THP-1 cells". Biochem. Biophys. Res. Commun. 296 (1): 48–53. doi:10.1016/s0006-291x(02)00835-5. PMID 12147225.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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