DSP-4
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Preferred IUPAC name N-[(2-Bromophenyl)methyl]-2-chloro-N-ethylethan-1-amine | |
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Chemical formula | C11H15BrClN |
Molar mass | 276.60 g/mol |
Density | 1.339 g/cm3 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
DSP-4, or N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine, is a neurotoxin selective for noradrenergic neurons, capable of crossing the blood–brain barrier.[1]
It exerts transient effects in peripheral sympathetic neurons, but more permanent changes within neurons of the central nervous system. It can induce long-term depletion in cortical and spinal levels of noradrenaline.[2]
See also
- 5,7-Dihydroxytryptamine
- MPTP
- Oxidopamine
References
- ^ Daw NW, Videen TO, Parkinson D, Rader RK (1985). "DSP-4 (N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine) Depletes Noradrenaline in Kitten Visual Cortex Without Altering the Effects of Monocular Deprivation". J. Neurosci. 5 (7): 1925–1933. doi:10.1523/jneurosci.05-07-01925.1985. PMC 6565098. PMID 3926960.
- ^ Jaim-Etcheverry G, Mari'a Zieher L (1980). "DSP-4: A novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats". Brain Res. 188 (2): 513–523. doi:10.1016/0006-8993(80)90049-9. PMID 7370771. S2CID 36955590.
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- DSP-4
- Oxidopamine (6-OHDA)
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine metabolism modulators
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