CRTC2

Protein-coding gene in the species Homo sapiens
CRTC2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4HTM

Identifiers
AliasesCRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDsOMIM: 608972; MGI: 1921593; HomoloGene: 18765; GeneCards: CRTC2; OMA:CRTC2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CRTC2
Genomic location for CRTC2
Band1q21.3Start153,947,669 bp[1]
End153,958,615 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CRTC2
Genomic location for CRTC2
Band3|3 F1Start90,161,470 bp[2]
End90,171,432 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • left ovary

  • right ovary

  • right hemisphere of cerebellum

  • right lung

  • spleen

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • canal of the cervix

  • body of uterus
Top expressed in
  • neural layer of retina

  • lumbar spinal ganglion

  • tail of embryo

  • genital tubercle

  • granulocyte

  • lip

  • muscle of thigh

  • cerebellar cortex

  • thymus

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • chromatin binding
  • protein binding
  • cAMP response element binding protein binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleus
  • nucleoplasm
Biological process
  • gluconeogenesis
  • histone H3-K9 acetylation
  • positive regulation of CREB transcription factor activity
  • viral process
  • regulation of transcription, DNA-templated
  • protein homotetramerization
  • toxin transport
  • glucose homeostasis
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

200186

74343

Ensembl

ENSG00000160741

ENSMUSG00000027936

UniProt

Q53ET0

Q3U182

RefSeq (mRNA)

NM_181715

NM_028881
NM_001357152

RefSeq (protein)

NP_859066

NP_083157
NP_001344081

Location (UCSC)Chr 1: 153.95 – 153.96 MbChr 3: 90.16 – 90.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[5][6][7]

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2[10] and YWHAQ.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
  6. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  7. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  8. ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585.
  9. ^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7): eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.
  10. ^ a b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
  11. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  • Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
  • Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228. S2CID 17404931.
  • Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (July 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
  • Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (September 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. Bibcode:2006PNAS..10314379W. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
  • Yang Q, Inoki K, Ikenoue T, Guan KL (October 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (June 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal. 26 (12): 2880–9. doi:10.1038/sj.emboj.7601715. PMC 1894761. PMID 17476304.
  • Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (June 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America. 104 (24): 10175–80. Bibcode:2007PNAS..10410175K. doi:10.1073/pnas.0704170104. PMC 1891214. PMID 17548807.

External links

  • CRTC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q53ET0 (Human CREB-regulated transcription coactivator 2) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q3U182 (Mouse CREB-regulated transcription coactivator 2) at the PDBe-KB.
  • v
  • t
  • e
Coactivators
Corepressors
ATP-dependent remodeling factors
  • Chromatin Structure Remodeling (RSC) Complex
  • SWI/SNF
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