CENPC1

Protein-coding gene in the species Homo sapiens

CENPC

Identifiers

Aliases

CENPC, CENP-C, CENPC1, MIF2, hcp-4, centromere protein C

External IDs

OMIM: 117141; MGI: 99700; HomoloGene: 1371; GeneCards: CENPC; OMA:CENPC - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.2	Start	67,468,762 bp^[1]
Band	4q13.2	End	67,545,503 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E1	Start	86,159,883 bp^[2]
Band	5\|5 E1	End	86,213,442 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

sural nerve

corpus callosum

bone marrow cells

thymus

body of pancreas

lymph node

endometrium

cervix

rectum

Top expressed in

spermatocyte

otic placode

superior cervical ganglion

abdominal wall

saccule

ganglionic eminence

medial ganglionic eminence

atrioventricular valve

dermis

vas deferens

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding centromeric DNA binding protein binding identical protein binding
Cellular component	pericentric heterochromatin chromosome chromosome, centromeric region kinetochore nucleus nucleoplasm cytosol nuclear body midbody cleavage furrow intercellular bridge Flemming body
Biological process	chromosome segregation cell division kinetochore assembly cell cycle CENP-A containing chromatin assembly attachment of mitotic spindle microtubules to kinetochore monopolar spindle attachment to meiosis I kinetochore mitotic cell cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1060


12617

Ensembl


ENSG00000145241


ENSMUSG00000029253

UniProt


Q03188


P49452

RefSeq (mRNA)


NM_001812 NM_001362481


NM_007683 NM_001345902 NM_001345903 NM_001345904

RefSeq (protein)


NP_001803 NP_001349410


NP_001332831 NP_001332832 NP_001332833 NP_031709

Location (UCSC)

Chr 4: 67.47 – 67.55 Mb

Chr 5: 86.16 – 86.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.^[5]^[6]

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029253 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
^ ^a ^b "Entrez Gene: CENPC1 centromere protein C 1".

External links

Human CENPC genome location and CENPC gene details page in the UCSC Genome Browser.

Saitoh H, Tomkiel J, Cooke CA, et al. (1992). "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate". Cell. 70 (1): 115–25. doi:10.1016/0092-8674(92)90538-N. PMID 1339310. S2CID 22014181.
Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator". J. Biol. Chem. 271 (31): 18767–74. doi:10.1074/jbc.271.31.18767. PMID 8702533.
Xie Y, Heng HH (1996). "FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21". Cytogenet. Cell Genet. 74 (3): 192–3. doi:10.1159/000134412. PMID 8941372.
Xie Y, Ni ZM, Gu JR, et al. (1997). "Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore". Cell Res. 7 (1): 13–9. doi:10.1038/cr.1997.2. PMID 9261558.
Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death". J. Cell Sci. 111. ( Pt 14) (14): 2029–41. doi:10.1242/jcs.111.14.2029. PMID 9645950.
Song K, Gronemeyer B, Lu W, et al. (2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C)". Exp. Cell Res. 275 (1): 81–91. doi:10.1006/excr.2002.5495. PMID 11925107.
Politi V, Perini G, Trazzi S, et al. (2002). "CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains". J. Cell Sci. 115 (Pt 11): 2317–27. doi:10.1242/jcs.115.11.2317. PMID 12006616.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Trazzi S, Bernardoni R, Diolaiti D, et al. (2003). "In vivo functional dissection of human inner kinetochore protein CENP-C". J. Struct. Biol. 140 (1–3): 39–48. doi:10.1016/S1047-8477(02)00506-3. PMID 12490152.
Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
Suzuki N, Nakano M, Nozaki N, et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID 14612452.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Chung TL, Hsiao HH, Yeh YY, et al. (2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides". J. Biol. Chem. 279 (38): 39653–62. doi:10.1074/jbc.M405637200. PMID 15272016.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Faragher AJ, Sun XM, Butterworth M, et al. (2007). "Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase". Mol. Biol. Cell. 18 (4): 1337–47. doi:10.1091/mbc.E06-05-0409. PMC 1838999. PMID 17287400.
Wong LH, Brettingham-Moore KH, Chan L, et al. (2007). "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere". Genome Res. 17 (8): 1146–60. doi:10.1101/gr.6022807. PMC 1933521. PMID 17623812.