C1orf38

Protein-coding gene in the species Homo sapiens
THEMIS2
Identifiers
AliasesTHEMIS2, C1orf38, ICB-1, thymocyte selection associated family member 2, ICB1, Chromosome 1 open reading frame 38
External IDsOMIM: 617856; MGI: 2446213; HomoloGene: 21009; GeneCards: THEMIS2; OMA:THEMIS2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for THEMIS2
Genomic location for THEMIS2
Band1p35.3Start27,872,543 bp[1]
End27,886,685 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for THEMIS2
Genomic location for THEMIS2
Band4|4 D2.3Start132,509,154 bp[2]
End132,523,698 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • granulocyte

  • blood

  • spleen

  • bone marrow cells

  • right lung

  • upper lobe of left lung

  • appendix

  • C1 segment

  • gallbladder
Top expressed in
  • granulocyte

  • lymph node

  • spleen

  • mesenteric lymph nodes

  • blood

  • stroma of bone marrow

  • gastrula

  • subcutaneous adipose tissue

  • submandibular gland

  • tibiofemoral joint
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleus
  • cytoplasm
Biological process
  • inflammatory response
  • immune system process
  • cell adhesion
  • T cell receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9473

230787

Ensembl

ENSG00000130775

ENSMUSG00000037731

UniProt

Q5TEJ8

Q91YX0

RefSeq (mRNA)

NM_001039477
NM_001105556
NM_001286113
NM_001286115
NM_004848

NM_001033308

RefSeq (protein)

NP_001034566
NP_001099026
NP_001273042
NP_001273044
NP_004839

NP_001028480

Location (UCSC)Chr 1: 27.87 – 27.89 MbChr 4: 132.51 – 132.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene.[5] The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712.[5] C1orf38 has been associated with cancer susceptibility.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130775 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037731 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Chromosome 1 open reading frame 38". Retrieved 2011-12-07.
  6. ^ Springwald A, Lattrich C, Seitz S, Ortmann O, Treeck O (July 2009). "Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility". Cancer Investigation. 27 (6): 669–672. doi:10.1080/07357900802620877. PMID 19308812. S2CID 205570175.

Further reading

  • Haselberger M, Springwald A, Konwisorz A, Lattrich C, Goerse R, Ortmann O, et al. (July 2011). "Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells". International Journal of Molecular Medicine. 28 (1): 121–127. doi:10.3892/ijmm.2011.663. PMID 21455565.
  • Springwald A, Lattrich C, Skrzypczak M, Goerse R, Ortmann O, Treeck O (November 2010). "Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression". Cancer Investigation. 28 (9): 904–909. doi:10.3109/07357907.2010.483511. PMID 20569072. S2CID 35017943.
  • Konwisorz A, Springwald A, Haselberger M, Goerse R, Ortmann O, Treeck O (March 2010). "Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells". Endocrine-Related Cancer. 17 (1): 147–157. doi:10.1677/ERC-09-0095. PMID 19942713.
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