Bicyclic phosphate

Class of chemical compounds

Bicyclic phosphate is a class of organophosphate compounds that are used as flame retardants, stabilizers and antioxidants. They are also used in spectroscopic studies.[1][2]

Some bicyclic phosphates, such as TBPS, TBPO and IPTBO, are highly toxic. They have toxicity comparable to nerve agents. However, they are not acetylcholinesterase inhibitors.[1] They act as GABA receptor antagonists and have potent convulsant effects.[2][3][4]

See also

  • Convulsant
  • TBPS
  • TBPO
  • IPTBO

References

  1. ^ a b Bellet, E. M.; Casida, J. E. (14 December 1973). "Bicyclic Phosphorus Esters: High Toxicity without Cholinesterase Inhibition". Science. 182 (4117): 1135–1136. Bibcode:1973Sci...182.1135B. doi:10.1126/science.182.4117.1135. PMID 4356280. S2CID 9462533.
  2. ^ a b Gupta, Ramesh C., ed. (2009). Handbook of toxicology of chemical warfare agents (1st ed.). London: Academic Press. ISBN 9780123744845.
  3. ^ BOWERY, N. G.; COLLINS, J. F.; HILL, R. G. (17 June 1976). "Bicyclic phosphorus esters that are potent convulsants and GABA antagonists". Nature. 261 (5561): 601–603. Bibcode:1976Natur.261..601B. doi:10.1038/261601a0. PMID 934303. S2CID 4184150.
  4. ^ Ellison, D. Hank (2007). Handbook of chemical and biological warfare agents (2nd ed.). Boca Raton, Fla.: CRC. ISBN 9780849314346.
  • v
  • t
  • e
  • Agents used in chemical warfare
  • incapacitation
  • riot control
Blood agentsBlister agents
Arsenicals
Sulfur mustards
Nitrogen mustards
Nettle agents
Other
Nerve agents
G-agents
V-agents
GV agents
  • GV (EA-5365)
Novichok agents
Carbamates
Other
Precursors
NeurotoxinsPulmonary/
choking agentsVomiting agentsIncapacitating
agentsLachrymatory
agentsMalodorant agentsCornea-clouding agentsBiological toxinsOther
  • v
  • t
  • e
GABA receptor antagonists
GABA synthesis inhibitors
Glycine receptor antagonists
Glutamate receptor agonists
Convulsant barbiturates
Other
  • v
  • t
  • e
Animal toxins
Bacterial
Cyanotoxins
Plant toxins
Mycotoxins
Pesticides
Nerve agents
Bicyclic phosphates
Cholinergic neurotoxins
Other
  • v
  • t
  • e
GABA receptor modulators
Ionotropic
GABAATooltip γ-Aminobutyric acid A receptor
GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABABTooltip γ-Aminobutyric acid B receptor
See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators


Stub icon

This neurotoxin article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e