BCAS2

Protein-coding gene in the species Homo sapiens


BCAS2
Identifiers
AliasesBCAS2, DAM1, SPF27, Snt309, breast carcinoma amplified sequence 2, pre-mRNA processing factor, BCAS2 pre-mRNA processing factor
External IDsOMIM: 605783; MGI: 1915433; HomoloGene: 4291; GeneCards: BCAS2; OMA:BCAS2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for BCAS2
Genomic location for BCAS2
Band1p13.2Start114,567,557 bp[1]
End114,581,629 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for BCAS2
Genomic location for BCAS2
Band3|3 F2.2Start103,078,971 bp[2]
End103,086,482 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Achilles tendon

  • palpebral conjunctiva

  • glutes

  • pons

  • endothelial cell

  • islet of Langerhans

  • parietal pleura

  • Skeletal muscle tissue of rectus abdominis

  • Pars compacta
Top expressed in
  • mandibular prominence

  • maxillary prominence

  • endocardial cushion

  • superior cervical ganglion

  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus

  • human fetus

  • atrioventricular valve

  • migratory enteric neural crest cell

  • somite
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • DNA replication factor A complex
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleolus
  • precatalytic spliceosome
  • Prp19 complex
  • nucleoplasm
  • nucleus
  • centrosome
  • nuclear speck
  • U2-type catalytic step 2 spliceosome
Biological process
  • RNA splicing, via transesterification reactions
  • mRNA processing
  • RNA splicing
  • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10286

68183

Ensembl

ENSG00000116752

ENSMUSG00000005687

UniProt

O75934

Q9D287

RefSeq (mRNA)

NM_005872

NM_026602
NM_001356330
NM_001356331

RefSeq (protein)

NP_005863

NP_080878
NP_001343259
NP_001343260

Location (UCSC)Chr 1: 114.57 – 114.58 MbChr 3: 103.08 – 103.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-splicing factor SPF27 is a protein that in humans is encoded by the BCAS2 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116752 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005687 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
  6. ^ Nagasaki K, Maass N, Manabe T, Hanzawa H, Tsukada T, Kikuchi K, Yamaguchi K (Aug 1999). "Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines". Cancer Lett. 140 (1–2): 219–26. doi:10.1016/S0304-3835(99)00091-9. PMID 10403562.
  7. ^ "Entrez Gene: BCAS2 breast carcinoma amplified sequence 2".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Qi C, Zhu YT, Chang J, et al. (2005). "Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2". Biochem. Biophys. Res. Commun. 328 (2): 393–8. doi:10.1016/j.bbrc.2004.12.187. PMID 15694360.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi:10.1016/S0304-3835(02)00055-1. PMID 12406557.
  • Maass N, Rösel F, Schem C, et al. (2002). "Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer". Cancer Lett. 185 (2): 219–23. doi:10.1016/S0304-3835(02)00286-0. PMID 12169396.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links


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