Adenosylcobinamide-phosphate synthase
Class of enzymes
Adenosylcobinamide-phosphate synthase | |||||||||
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Identifiers | |||||||||
EC no. | 6.3.1.10 | ||||||||
CAS no. | 905988-16-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Adenosylcobinamide-phosphate synthase (EC 6.3.1.10, CbiB) is an enzyme with systematic name adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming).[1][2] This enzyme catalyses the following chemical reaction
- (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate ADP + phosphate + adenosylcobinamide phosphate
- (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol ADP + phosphate + adenosylcobinamide
One of the substrates, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81). This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.
See also
References
- ^ Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I (April 2002). "Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica". Biochemistry. 41 (15): 4798–808. CiteSeerX 10.1.1.564.9386. doi:10.1021/bi012111w. PMID 11939774.
- ^ Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports. 19 (4): 390–412. doi:10.1039/b108967f. PMID 12195810.
External links
- Adenosylcobinamide-phosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- v
- t
- e
- Aminoacyl tRNA synthetase
- Alanine
- Arginine
- Asparagine
- Aspartate
- Cysteine
- D-alanine—poly(phosphoribitol) ligase
- Glutamate
- Glutamine
- Glycine
- Histidine
- Isoleucine
- Leucine
- Lysine
- Methionine
- Phenylalanine
- Proline
- Serine
- Threonine
- Tryptophan
- Tyrosine
- Valine