ATP5G1

Protein-coding gene in the species Homo sapiens
ATP5MC1
Identifiers
AliasesATP5MC1, ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9), ATP synthase membrane subunit c locus 1, ATP5G1
External IDsOMIM: 603192; MGI: 107653; HomoloGene: 38017; GeneCards: ATP5MC1; OMA:ATP5MC1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ATP5MC1
Genomic location for ATP5MC1
Band17q21.32Start48,892,765 bp[1]
End48,895,871 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for ATP5MC1
Genomic location for ATP5MC1
Band11|11 DStart95,959,678 bp[2]
End95,966,496 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • mucosa of transverse colon

  • right auricle

  • rectum

  • left ventricle

  • muscle of thigh

  • gastrocnemius muscle

  • body of stomach

  • right frontal lobe

  • prefrontal cortex
Top expressed in
  • right kidney

  • muscle of thigh

  • blastocyst

  • morula

  • lip

  • superior frontal gyrus

  • yolk sac

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • lipid binding
  • transporter activity
  • proton transmembrane transporter activity
  • protein binding
  • proton-transporting ATP synthase activity, rotational mechanism
Cellular component
  • proton-transporting ATP synthase complex, coupling factor F(o)
  • membrane
  • integral component of membrane
  • mitochondrion
  • mitochondrial membranes
  • proton-transporting two-sector ATPase complex, proton-transporting domain
  • mitochondrial proton-transporting ATP synthase complex
  • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
  • mitochondrial inner membrane
Biological process
  • ion transport
  • ATP biosynthetic process
  • ATP synthesis coupled proton transport
  • cristae formation
  • mitochondrial ATP synthesis coupled proton transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

516

11951

Ensembl

ENSG00000159199

ENSMUSG00000006057

UniProt

P05496

Q9CR84

RefSeq (mRNA)

NM_005175
NM_001002027

NM_001161419
NM_007506

RefSeq (protein)

NP_001002027
NP_005166

NP_001154891
NP_031532

Location (UCSC)Chr 17: 48.89 – 48.9 MbChr 11: 95.96 – 95.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.[5][6]

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159199 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006057 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dyer MR, Walker JE (Jul 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". The Biochemical Journal. 293 (Pt 1): 51–64. doi:10.1042/bj2930051. PMC 1134319. PMID 8328972.
  6. ^ a b "Entrez Gene: ATP5MC1 ATP synthase membrane subunit c locus 1".

External links

Further reading

  • Farrell LB, Nagley P (May 1987). "Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex". Biochemical and Biophysical Research Communications. 144 (3): 1257–64. doi:10.1016/0006-291X(87)91446-X. PMID 2883974.
  • Yan WL, Lerner TJ, Haines JL, Gusella JF (Nov 1994). "Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)". Genomics. 24 (2): 375–7. doi:10.1006/geno.1994.1631. PMID 7698763.
  • Higuti T, Kawamura Y, Kuroiwa K, Miyazaki S, Tsujita H (Apr 1993). "Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1173 (1): 87–90. doi:10.1016/0167-4781(93)90249-D. PMID 8485160.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Elston T, Wang H, Oster G (Jan 1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
  • Wang H, Oster G (Nov 1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
  • Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Cross RL (Jan 2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Wang HL, Zhu ZM, Yerle M, Wu X, Wang H, Yang SL, Li K (2005). "Full-length coding sequences and mapping of porcine ATP6VOE and ATP5G1 genes". Cytogenetic and Genome Research. 109 (4): 533. doi:10.1159/000084223. PMID 15906478.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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