ATP1B3

Protein-coding gene in the species Homo sapiens
ATP1B3
Identifiers
AliasesATP1B3, ATPB-3, CD298, ATPase Na+/K+ transporting subunit beta 3
External IDsOMIM: 601867; MGI: 107788; HomoloGene: 37510; GeneCards: ATP1B3; OMA:ATP1B3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ATP1B3
Genomic location for ATP1B3
Band3q23Start141,876,124 bp[1]
End141,926,549 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for ATP1B3
Genomic location for ATP1B3
Band9 E3.3|9 50.31 cMStart96,214,708 bp[2]
End96,246,495 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • skin of thigh

  • skin of hip

  • gingival epithelium

  • mucosa of colon

  • mucosa of pharynx

  • stromal cell of endometrium

  • vulva

  • mucosa of sigmoid colon

  • mucosa of transverse colon
Top expressed in
  • sciatic nerve

  • epithelium of lens

  • seminiferous tubule

  • choroid plexus of fourth ventricle

  • corneal stroma

  • gastrula

  • molar

  • utricle

  • skin of external ear

  • superior surface of tongue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATPase binding
  • P-type sodium:potassium-exchanging transporter activity
  • ATPase activator activity
Cellular component
  • cytoplasm
  • integral component of membrane
  • membrane
  • melanosome
  • plasma membrane
  • sodium:potassium-exchanging ATPase complex
  • caveola
  • extracellular exosome
Biological process
  • regulation of cardiac conduction
  • positive regulation of ATP-dependent activity
  • positive regulation of sodium ion export across plasma membrane
  • sodium ion transport
  • cellular sodium ion homeostasis
  • sodium ion export across plasma membrane
  • metal ion transport
  • positive regulation of potassium ion import across plasma membrane
  • protein stabilization
  • ion transport
  • cellular potassium ion homeostasis
  • potassium ion transport
  • membrane repolarization
  • ion transmembrane transport
  • protein localization to plasma membrane
  • leukocyte migration
  • positive regulation of potassium ion transmembrane transporter activity
  • establishment or maintenance of transmembrane electrochemical gradient
  • transport
  • potassium ion import across plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

483

11933

Ensembl

ENSG00000069849

ENSMUSG00000032412

UniProt

P54709

P97370

RefSeq (mRNA)

NM_001679

NM_007502
NM_001357212
NM_001357213

RefSeq (protein)

NP_001670

NP_031528
NP_001344141
NP_001344142

Location (UCSC)Chr 3: 141.88 – 141.93 MbChr 9: 96.21 – 96.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene.[5][6][7] ATP1B3 has also been designated as CD298 (cluster of differentiation 298).

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069849 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032412 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Malik N, Canfield VA, Beckers MC, Gros P, Levenson R (Nov 1996). "Identification of the mammalian Na,K-ATPase 3 subunit". J Biol Chem. 271 (37): 22754–8. doi:10.1074/jbc.271.37.22754. PMID 8798450.
  6. ^ Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R (Mar 1998). "Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene". Mamm Genome. 9 (2): 136–43. doi:10.1007/s003359900704. PMID 9457675. S2CID 31228553.
  7. ^ a b "Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide".

Further reading

  • Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
  • Jørgensen PL (1982). "Mechanism of the Na+, K+ pump. Protein structure and conformations of the pure (Na+ +K+)-ATPase". Biochim. Biophys. Acta. 694 (1): 27–68. doi:10.1016/0304-4157(82)90013-2. PMID 6289898.
  • Chiampanichayakul S, Szekeres A, Khunkaewla P, et al. (2003). "Engagement of Na,K-ATPase beta3 subunit by a specific mAb suppresses T and B lymphocyte activation". Int. Immunol. 14 (12): 1407–14. doi:10.1093/intimm/dxf112. PMID 12456588.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519. S2CID 581283.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Chiampanichayakul S, Khunkaewla P, Pata S, Kasinrerk W (2007). "Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells". Tissue Antigens. 68 (6): 509–17. doi:10.1111/j.1399-0039.2006.00726.x. PMID 17176442.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Aughey RJ, Murphy KT, Clark SA, et al. (2007). "Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes". J. Appl. Physiol. 103 (1): 39–47. doi:10.1152/japplphysiol.00236.2006. PMID 17446412. S2CID 7370462.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
1–5051–100101–150151–200201–250251–300301–350
  • v
  • t
  • e
3.6.1
3.6.2
3.6.3-4: ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
  • ATP4A
Other P-type ATPase
3.6.4
3.6.5: GTPase
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
3.6.5.3: Protein-synthesizing GTPase
3.6.5.5-6: Polymerization motors


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e