ARPC1A

Mammalian protein found in Homo sapiens
ARPC1A
Identifiers
AliasesARPC1A, Arc40, HEL-68, SOP2Hs, SOP2L, HEL-S-307, actin related protein 2/3 complex subunit 1A
External IDsOMIM: 604220; MGI: 1928896; HomoloGene: 4675; GeneCards: ARPC1A; OMA:ARPC1A - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ARPC1A
Genomic location for ARPC1A
Band7q22.1Start99,325,898 bp[1]
End99,366,262 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for ARPC1A
Genomic location for ARPC1A
Band5|5 G2Start145,020,640 bp[2]
End145,045,571 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • gonad

  • hippocampus proper

  • hypothalamus

  • Brodmann area 9

  • amygdala

  • substantia nigra

  • body of stomach

  • putamen

  • nucleus accumbens
Top expressed in
  • transitional epithelium of urinary bladder

  • olfactory tubercle

  • superior frontal gyrus

  • nucleus accumbens

  • dentate gyrus of hippocampal formation granule cell

  • sciatic nerve

  • islet of Langerhans

  • lip

  • globus pallidus

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • actin binding
  • actin filament binding
Cellular component
  • cytoplasm
  • cytosol
  • arp2/3 protein complex
  • extracellular exosome
  • cytoskeleton
  • actin cytoskeleton
  • muscle cell projection membrane
  • nucleus
  • site of double-strand break
Biological process
  • ephrin receptor signaling pathway
  • regulation of actin filament polymerization
  • actin cytoskeleton organization
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • Arp2/3 complex-mediated actin nucleation
  • membrane organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10552

56443

Ensembl

ENSG00000241685

ENSMUSG00000029621

UniProt

Q92747

Q9R0Q6

RefSeq (mRNA)

NM_006409
NM_001190996

NM_019767

RefSeq (protein)

NP_001177925
NP_006400

NP_062741

Location (UCSC)Chr 7: 99.33 – 99.37 MbChr 5: 145.02 – 145.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.[5][6][7]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241685 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029621 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (Jan 1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function". EMBO J. 15 (23): 6426–37. doi:10.1002/j.1460-2075.1996.tb01034.x. PMC 452468. PMID 8978670.
  6. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  7. ^ a b "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa".

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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