ARFIP2

Protein-coding gene in the species Homo sapiens
ARFIP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1I49, 1I4D, 1I4L, 1I4T, 4DCN

Identifiers
AliasesARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDsOMIM: 601638; MGI: 1924182; HomoloGene: 8234; GeneCards: ARFIP2; OMA:ARFIP2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ARFIP2
Genomic location for ARFIP2
Band11p15.4Start6,474,683 bp[1]
End6,481,479 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ARFIP2
Genomic location for ARFIP2
Band7|7 E3Start105,283,410 bp[2]
End105,289,623 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • olfactory zone of nasal mucosa

  • beta cell

  • body of pancreas

  • anterior pituitary

  • body of stomach

  • right uterine tube

  • trachea

  • rectum

  • minor salivary glands

  • right lobe of thyroid gland
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • lacrimal gland

  • superior frontal gyrus

  • pyloric antrum

  • genital tubercle

  • parotid gland

  • ventricular zone

  • tail of embryo

  • cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-4-phosphate binding
  • protein domain specific binding
  • protein binding
  • GTP binding
  • identical protein binding
  • cadherin binding
  • GTP-dependent protein binding
  • phospholipid binding
Cellular component
  • cell cortex
  • trans-Golgi network membrane
  • plasma membrane
  • ruffle
  • cytosol
  • cytoplasm
Biological process
  • ruffle organization
  • small GTPase mediated signal transduction
  • actin cytoskeleton organization
  • regulation of Arp2/3 complex-mediated actin nucleation
  • lamellipodium assembly
  • intracellular protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23647

76932

Ensembl

ENSG00000132254

ENSMUSG00000030881

UniProt

P53365

Q8K221

RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)
NP_001229783
NP_001229784
NP_001229785
NP_036534
NP_001357335

NP_001357337
NP_001357338
NP_001357340
NP_001357341
NP_001357342
NP_001363487
NP_001363488
NP_001363489
NP_001363490
NP_001363491
NP_001363492
NP_001363493

NP_084078

Location (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.28 – 105.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]

Interactions

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030881 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
  6. ^ a b c Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
  7. ^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
  8. ^ D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  9. ^ a b c Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  10. ^ Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. S2CID 4324211.

Further reading

  • D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
  • Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. S2CID 4324211.
  • Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
  • Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (March 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752. S2CID 10881911.
  • Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  • Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (June 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

  • v
  • t
  • e
  • 1i49: CRYSTAL STRUCTURE ANALYSIS OF ARFAPTIN
    1i49: CRYSTAL STRUCTURE ANALYSIS OF ARFAPTIN
  • 1i4d: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21)
    1i4d: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21)
  • 1i4l: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41)
    1i4l: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41)
  • 1i4t: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GMPPNP IN COMPLEX WITH ARFAPTIN
    1i4t: CRYSTAL STRUCTURE ANALYSIS OF RAC1-GMPPNP IN COMPLEX WITH ARFAPTIN
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