ANKRD15

Protein-coding gene in the species Homo sapiens
KANK1
Identifiers
AliasesKANK1, ANKRD15, CPSQ2, KANK, KN motif and ankyrin repeat domains 1
External IDsOMIM: 607704; MGI: 2147707; HomoloGene: 17706; GeneCards: KANK1; OMA:KANK1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for KANK1
Genomic location for KANK1
Band9p24.3Start470,291 bp[1]
End746,105 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for KANK1
Genomic location for KANK1
Band19|19 BStart25,214,339 bp[2]
End25,411,860 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • Descending thoracic aorta

  • ascending aorta

  • cardiac muscle tissue of right atrium

  • popliteal artery

  • tibial arteries

  • gingival epithelium

  • myocardium of left ventricle

  • saphenous vein

  • right auricle
Top expressed in
  • fourth ventricle

  • choroid plexus of fourth ventricle

  • hand

  • interventricular septum

  • Dermatocranium

  • membranous bone

  • basilar part of occipital bone

  • ascending aorta

  • aortic valve

  • inner renal medulla
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • beta-catenin binding
  • protein binding
Cellular component
  • cytoplasm
  • cell projection
  • membrane
  • plasma membrane
  • ruffle membrane
  • nucleus
Biological process
  • negative regulation of neuron projection development
  • regulation of transcription, DNA-templated
  • negative regulation of actin filament polymerization
  • negative regulation of ruffle assembly
  • negative regulation of Rho protein signal transduction
  • positive regulation of wound healing
  • transcription, DNA-templated
  • positive regulation of Wnt signaling pathway
  • negative regulation of insulin receptor signaling pathway
  • negative regulation of cell migration
  • negative regulation of lamellipodium morphogenesis
  • negative regulation of substrate adhesion-dependent cell spreading
  • regulation of establishment of cell polarity
  • positive regulation of canonical Wnt signaling pathway
  • regulation of Rho protein signal transduction
  • glomerular visceral epithelial cell migration
  • cell population proliferation
  • actin cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23189

107351

Ensembl

ENSG00000107104

ENSMUSG00000032702

UniProt

Q14678

n/a

RefSeq (mRNA)
NM_001256876
NM_001256877
NM_015158
NM_153186
NM_001354331

NM_001354332
NM_001354333
NM_001354334
NM_001354335
NM_001354336
NM_001354337
NM_001354338
NM_001354339
NM_001354340
NM_001354341
NM_001354342
NM_001354343
NM_001354344

NM_181404
NM_001348180

RefSeq (protein)
NP_001243805
NP_001243806
NP_055973
NP_694856
NP_001341260

NP_001341261
NP_001341262
NP_001341263
NP_001341264
NP_001341265
NP_001341266
NP_001341267
NP_001341268
NP_001341269
NP_001341270
NP_001341271
NP_001341272
NP_001341273

n/a

Location (UCSC)Chr 9: 0.47 – 0.75 MbChr 19: 25.21 – 25.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.[5][6][7]

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107104 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032702 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem. 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830.
  6. ^ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
  7. ^ a b "Entrez Gene: ANKRD15 ankyrin repeat domain 15".

External links

Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Roy BC, Aoyagi T, Sarkar S, et al. (2005). "Pathological characterization of Kank in renal cell carcinoma". Exp. Mol. Pathol. 78 (1): 41–8. doi:10.1016/j.yexmp.2004.08.012. PMID 15596059.
  • Wang Y, Onishi Y, Kakinuma N, et al. (2005). "Alternative splicing of the human Kank gene produces two types of Kank protein". Biochem. Biophys. Res. Commun. 330 (4): 1247–53. doi:10.1016/j.bbrc.2005.03.106. PMID 15823577.
  • Wang Y, Kakinuma N, Zhu Y, Kiyama R (2007). "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin". J. Cell Sci. 119 (Pt 19): 4002–10. doi:10.1242/jcs.03169. PMID 16968744. S2CID 14196261.


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