Protein-coding gene in the species Homo sapiens
| ACTL6B |
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| Identifiers |
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| Aliases | ACTL6B, ACTL6, BAF53B, arpNalpha, actin like 6B, EIEE76, IDDSSAD, DEE76, SMARCN2 |
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| External IDs | OMIM: 612458; MGI: 1933548; HomoloGene: 81844; GeneCards: ACTL6B; OMA:ACTL6B - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 7 (human)[1] |
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| | Band | 7q22.1 | Start | 100,643,097 bp[1] |
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| End | 100,656,448 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 5 (mouse)[2] |
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| | Band | 5|5 G2 | Start | 137,553,517 bp[2] |
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| End | 137,569,582 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right hemisphere of cerebellum
- right frontal lobe
- ganglionic eminence
- Brodmann area 9
- prefrontal cortex
- nucleus accumbens
- cingulate gyrus
- anterior cingulate cortex
- putamen
- caudate nucleus
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| | Top expressed in | - superior frontal gyrus
- dentate gyrus of hippocampal formation granule cell
- primary visual cortex
- perirhinal cortex
- subiculum
- entorhinal cortex
- cerebellar cortex
- olfactory tubercle
- dorsomedial hypothalamic nucleus
- CA3 field
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - structural constituent of cytoskeleton
- transcription coactivator activity
- chromatin binding
| | Cellular component | - nucleus
- nucleolus
- nBAF complex
- SWI/SNF complex
- NuA4 histone acetyltransferase complex
| | Biological process | - nervous system development
- regulation of transcription, DNA-templated
- spinal cord development
- regulation of transcription by RNA polymerase II
- transcription, DNA-templated
- chromatin remodeling
- cytoskeleton organization
- chromatin organization
- positive regulation of nucleic acid-templated transcription
- histone H4 acetylation
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 7: 100.64 – 100.66 Mb | Chr 5: 137.55 – 137.57 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.[5][6]
Function
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.[6]
Interactions
ACTL6B has been shown to interact with CTBP1.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000077080 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029712 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
- ^ a b "Entrez Gene: ACTL6B actin-like 6B".
- ^ Oma Y, Nishimori K, Harata M (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.
External links
Further reading
- Schafer DA, Schroer TA (2000). "Actin-related proteins". Annu. Rev. Cell Dev. Biol. 15: 341–363. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci. Biotechnol. Biochem. 63 (5): 917–923. doi:10.1271/bbb.63.917. PMID 10380635.
- Olave I, Wang W, Xue Y, Kuo A, Crabtree GR (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–2517. doi:10.1101/gad.992102. PMC 187451. PMID 12368262.
- Kuroda Y, Oma Y, Nishimori K, Ohta T, Harata M (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. 299 (2): 328–334. doi:10.1016/S0006-291X(02)02637-2. PMID 12437990.
- Oma Y, Nishimori K, Harata M (2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. PMID 12565893.
