ACSM2B

Protein-coding gene in the species Homo sapiens
ACSM2B
Identifiers
AliasesACSM2B, ACSM2, HXMA, HYST1046, acyl-CoA synthetase medium-chain family member 2B, acyl-CoA synthetase medium chain family member 2B
External IDsOMIM: 614359; MGI: 2385289; HomoloGene: 89289; GeneCards: ACSM2B; OMA:ACSM2B - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ACSM2B
Genomic location for ACSM2B
Band16p12.3Start20,536,226 bp[1]
End20,576,427 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ACSM2B
Genomic location for ACSM2B
Band7|7 F2Start119,153,563 bp[2]
End119,199,913 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • renal cortex

  • human kidney

  • testicle

  • gonad

  • epithelium of colon

  • sural nerve

  • left uterine tube

  • renal medulla

  • muscle of thigh
Top expressed in
  • right kidney

  • proximal tubule

  • human kidney

  • primary visual cortex

  • morula

  • muscle of thigh

  • hair follicle

  • zygote

  • superior frontal gyrus

  • renal corpuscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ligase activity
  • catalytic activity
  • ATP binding
  • metal ion binding
  • butyrate-CoA ligase activity
  • CoA-ligase activity
  • fatty-acyl-CoA synthase activity
  • fatty acid ligase activity
  • molecular function
Cellular component
  • mitochondrion
  • mitochondrial matrix
Biological process
  • xenobiotic metabolic process
  • metabolism
  • fatty acid metabolic process
  • lipid metabolism
  • fatty acid biosynthetic process
  • acyl-CoA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

348158

233799

Ensembl

ENSG00000066813

ENSMUSG00000030945

UniProt

Q68CK6

Q8K0L3

RefSeq (mRNA)

NM_001105069
NM_182617

NM_001177977
NM_001177978
NM_146197

RefSeq (protein)

NP_001098539
NP_872423

NP_001171448
NP_001171449
NP_666309

Location (UCSC)Chr 16: 20.54 – 20.58 MbChr 7: 119.15 – 119.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-coenzyme A synthetase ACSM2B, mitochondrial is an enzyme that in humans is encoded by the ACSM2B gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000066813 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030945 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vessey DA, Lau E, Kelley M, Warren RS (Mar 2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria". J Biochem Mol Toxicol. 17 (1): 1–6. doi:10.1002/jbt.10056. PMID 12616642. S2CID 13396633.
  6. ^ "Entrez Gene: ACSM2 acyl-CoA synthetase medium-chain family member 2".

External links

Further reading

  • Lindner I, Rubin D, Helwig U, et al. (2006). "The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population". Mol Nutr Food Res. 50 (3): 270–4. doi:10.1002/mnfr.200500241. PMID 16521160.
  • Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
  • Vessey DA, Kelley M, Warren RS (2004). "Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver". J. Biochem. Mol. Toxicol. 18 (2): 100–6. doi:10.1002/jbt.20009. PMID 15122652. S2CID 8154380.
  • Vessey DA, Kelley M (2001). "Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase". Biochem. J. 357 (Pt 1): 283–8. doi:10.1042/0264-6021:3570283. PMC 1221953. PMID 11415461.
  • Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids". Biochim. Biophys. Acta. 1428 (2–3): 455–62. doi:10.1016/s0304-4165(99)00088-4. PMID 10434065.
  • Vessey DA, Hu J (1997). "Isolation from bovine liver mitochondria and characterization of three distinct carboxylic acid: CoA ligases with activity toward xenobiotics". J. Biochem. Toxicol. 10 (6): 329–37. doi:10.1002/jbt.2570100608. PMID 8934636.
  • Vessey DA, Hu J, Kelley M (1997). "Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria". J. Biochem. Toxicol. 11 (2): 73–8. doi:10.1002/(SICI)1522-7146(1996)11:2<73::AID-JBT4>3.0.CO;2-R. PMID 8884467.


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