8-Cyclopentyl-1,3-dimethylxanthine
Chemical compound
- None
- In general: uncontrolled
- 8-Cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione
- 35873-49-5
Y
- 1917
- 385
- 1843 Y
- U7PWT4CPL5
- CHEBI:109538
- ChEMBL106265 Y
- DTXSID70189432
- Interactive image
- Cn3c(=O)c2nc(C1CCCC1)[nH]c2n(C)c3=O
InChI
- InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)Y
- Key:SCVHFRLUNIOSGI-UHFFFAOYSA-NY
8-Cyclopentyl-1,3-dimethylxanthine (8-Cyclopentyltheophylline, 8-CPT, CPX) is a drug which acts as a potent and selective antagonist for the adenosine receptors, with some selectivity for the A1 receptor subtype, as well as a non-selective phosphodiesterase inhibitor. It has stimulant effects in animals with slightly higher potency than caffeine.[1][2]
See also
References
- ^ Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology. 95 (1): 19–24. doi:10.1007/bf00212759. PMID 3133696. S2CID 11539292.
- ^ Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, et al. (July 2003). "Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration". Neuropsychopharmacology. 28 (7): 1281–91. doi:10.1038/sj.npp.1300167. PMID 12700682.
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(ligands)
| P0 (adenine) |
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| P1 (adenosine) |
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| P2 (nucleotide) |
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(blockers)
| CNTsTooltip Concentrative nucleoside transporters |
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| ENTsTooltip Equilibrative nucleoside transporters | |
| PMATTooltip Plasma membrane monoamine transporter |
(inhibitors)
| XOTooltip Xanthine oxidase | |
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| Others |
See also: Receptor/signaling modulators
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