3-hydroxymethylcephem carbamoyltransferase

In enzymology, a 3-hydroxymethylcephem carbamoyltransferase (EC 2.1.3.7) is an enzyme that catalyzes the chemical reaction

carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate ${\displaystyle \rightleftharpoons }$ phosphate + a 3-carbamoyloxymethylcephem

Thus, the two substrates of this enzyme are carbamoyl phosphate and 3-hydroxymethylceph-3-em-4-carboxylate, whereas its two products are phosphate and 3-carbamoyloxymethylcephem.

This enzyme belongs to the family of transferases, that transfer one-carbon groups, specifically the carboxy- and carbamoyltransferases.

The systematic name of this enzyme class is carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase.

This enzyme has at least one effector, ATP.

References

• Brewer SJ, Taylor PM, Turner MK (1980). "An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus". Biochem. J. 185 (3): 555–64. PMC 1161431. PMID 6248024.